Endocrine Abstracts

This study examined the action of GH on secretory activity and apoptosis (A) in porcine ovarian granulosa cells, as well as the role of protein kinase A (PKA), mitogen-activated protein kinase (MAPK), tyrosine kinase (TK), protein kinase G (PKG) and cyclin-dependent cdc2/p34 kinase in the mediation of its actions. The effects of exogenous pGH, with or without blockers of PKA (KT5720, Rp-cAMPS), MAPK (PD98059), TK (genistein, lavendustin), PKG (Rp-Br-PET-cGMPS, KT5823) and cdc2...

Myostatin is expressed predominantly in skeletal muscle and at significantly lower levels in adipose tissue. The loss of myostatin by gene disruption prevents an age-related increase in adipose tissue mass and partially attenuates the obese and diabetic phenotypes. Inhibition of myostatin signaling could be useful to prevent and/or treat obesity and diabetes. Male OLETF and LETO rats as non-diabetic controls were treated with or without ALA (100 mg/kg per day) and/or insulin (...